Selenium deficiency and low vitamin E

Selenium is a micronutrient that is essential for the proper functioning of all organisms. Selenium, in the form of selenoproteins, carries out various functions in normal health and metabolism. This element is a cofactor of many enzymes, for example, glutathione peroxidase or thioredoxin reductase.

Selenium plays a role in the immune system functioning and the progression of HIV to AIDS. Selenium deficiency has been implicated in cardiovascular disease, infertility, myodegenerative diseases, and cognitive decline.

Selenium exhibits synergy with vitamin E. In metabolic processes, sulfur amino acids such

as cystine and methionine are closely associated with it. The combined interaction of selenium and

tocopherol gives the best results in the protection of organs against the destructive effects of free radicals. Combined administration of selenium and vitamin E results in an immunostimulatory effect.

Selenium deficiency occurs when there is inadequate dietary intake of selenium, typically due to a scarcity of selenium sources in a given region. Interestingly, low vitamin E intake may enhance the effect of selenium deficiency, which is associated with increased risk of fatal cancer.

Individuals whose blood (serum) selenium level is low with deficiencies of vitamin E accompanied are at the increased risk of developing cancer. In healthy individuals, the level of this element in blood is higher by several percent in comparison with those who suffer from cancer.
Selenium deficiency and low vitamin E

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